Treatment for renovascular hypertension.

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Treatment for renovascular hypertension.

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A half century ago, Goldblatt described the effect of renal ischemia on blood pressure. Motivated by inadequate pharmacological therapies for hypertension (HBP), the substantial risks of persistently elevated blood pressure, and the possibility of curing an important disease, clinicians soon thereafter sought to apply Goldblatt's findings, initially by removal of suspected culprit kidneys and l...

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Renovascular Hypertension: Pathophysiology, Diagnosis, and Treatment

Renovascular hypertension can result from renal artery lesions involving the main renal artery, or its branches. It is generally felt that the elevation of blood pressure results from excessive systemic vasoconstriction secondary to enhanced renin secretion by one or part of one kidney. Renin secretion is enhanced because of constriction of the renal artery and resultant intrarenal ischemia. Cl...

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Renovascular Hypertension

The effect of hypertension and of therapy by converting enzyme inhibitor (S 9490-3, perindopril) on the function and structure of large arteries has been studied in two-kidney, one-clip Gddblatt hypertensive rats. After one month without treatment, clipped hypertensive rats (n = 24) and sham-operated rats (n = 24) were randomly allocated to treatment by S 9490,1 mg/kg once a day (n = 24) or to ...

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Renovascular hypertension.

If only 1 per cent of the 23 million hypertensive patients in the United States had renovascular hypertension, many patients would be denied the chance for cure. Strong clinical suspicion plus arteriography are the mainstays of diagnosis. Positive renal vein renin studies provide the best preoperative evidence for cure by operation, but many patients with negative studies benefit from operation...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 1985

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.60.11.1105